Search for Radioprotective Compounds. Part XIX. PROTECTION PROVIDED TO MICE BY ORAL ADMINISTRATION OF LIPID- AND WATER-SOLUBLE COMPOUNDS

Authors
  1. Grant, G.A.
  2. Leach, K.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
Forty-two compounds previously screened at the Walter Reed Army Institute of Research were selected for further evaluation. The compounds were administered orally to mice prior to gamma irradiation. The LD sub 50/30 was computed and dose reduction factors determined. Dose reduction factors up to 1.45 were obtained for both water- and lipid-soluble compounds with administered oral doses of 100 mg/kg or less. The relationship between chemical structure and protective activity of the compounds is discussed.
Report Number
827 —
Date of publication
15 Oct 1980
Number of Pages
59
DSTKIM No
81-00226
CANDIS No
31401
Format(s):
Hardcopy;Originator's fiche received by DSIS

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