Reducing the Dose of Combined Caffeine and Ephedrine Preserves the Ergogenic Effect


  1. Bell, D.G.
  2. Jacobs, I.
  3. McLellan, T.M.
  4. Zamecnik, J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Ingestion of a combination of 5 mg - kg 1(-) caffeine (C), and 1 mg - kg 1(-) ephedrine (E) was reported to have an ergogenic effect on high intentiy aerobic exercise performance, but 25% of the subjects experienced vomiting and nausea while engaging in hard exercise after the treatment. The present study was undertaken to investigate whether reduced levels of C+E would alleviate the problem and maintain the ergogenic effect. Twelve healthy untrained male subjects completed four randomized and double-blind, cycle ergometer trials to exhaustion at a power output equivalent to -85% VO2peak 1.5-2 hours after ingesting a placebo (P) or a mixture of C+E in the following doses: 5 mg - kg 1(-) of C plus 0.8 mg - kg 1(-) of E (CLE); 4 mg - kg 1(-) of C plus 1 mg - kg 1(-) of E (LCE); or 4 mg - kg 1(-) of C plus 0.8 mg - kg 1(-) of E (LCE). Trials were separated by 1 wk. Venous blood samples were obtained and anlyized for caffeine and ephedrine levels 1.5 h post-drug ingestion. TRUNCATED
Ergogenic aids;Physical training;Ergogenic effects;Human performance
Report Number
DCIEM-SL-1999-061 — Scientific Literature
Date of publication
01 Mar 2000
Number of Pages
Reprinted from
Aviation, Space, and Environmental Medicine, vol 71, no 4, 2000, p 415-419
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