INHIBITION OF THE ETHANOL-INDUCED PRESYNAPTIC RELEASE OF ACETYLCHOLINE BY HEMICHOLINIUM-3

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Various concentrations of ethanol (0.29 - 1.09 M) potentiated the indirect supramaximal twitch in the rat diaphragm (RD) and chick biventer cervicis (CBC) preparations. Ethanol (1.09 M) produced a contraction of the muscle. Ethanol (0.43 M - 0.72 M) was found to antagonize the curare neuromuscular (NM) blockade but not the hemicholinium -3 (HC-3) blockade in both preparations. However, if ethanol was applied after washout of HC-3 a potentiation of the twitch response was noted. The results suggest that HC-3 but not curare inhibits the ethanol-induced release of acetylcholine from the presynaptic nerve terminal.
Report Number
TP-462 — Technical Paper
Date of publication
15 Jun 1977
Number of Pages
21
DSTKIM No
77-03385
CANDIS No
100091
Format(s):
Hardcopy;Originator's fiche received by DSIS

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