EFFECTS OF TWO CHOLINESTERASE INHIBITORS UPON ELECTROENCEPHALOGRAM, HEART RATE, AND RESPIRATION WHEN ADMINISTERED SIMULTANEOUSLY TO THE MONKEY

Authors
  1. Lipp, J.A.
  2. Linderman, T.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys were given GD and pyridostigmine alone and simultaneously and the effects upon the EEG, heart rate and respiration were recorded and compared. The doses of pyridostigmine used were 0.2 and 0.3 mg/kg while the doses of GD were 3 and 4 mu g/kg. All drugs were administered by IM injection. Neither dose of GD, when given alone, induced any significant change in EEG activity, but both doses produced a decrease in both heart rate and respiration. Neither dose of pyridostigmine when given alone induced any significant change in the EEG pattern, but both doses produced a decrease in both heart rate and respiration.
Report Number
TP-458 —
Date of publication
15 Jul 1977
Number of Pages
16
DSTKIM No
77-03914
CANDIS No
100600
Format(s):
Hardcopy;Originator's fiche received by DSIS

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