TOXICOLOGY OF DMMPA. PART II. THE EFFECTS OF CHRONIC APPLICATION OF DMMPA TO TEST ANIMALS

Authors
  1. Coleman, I.W.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The effects of chronic daily dosing of dimethyly morpholinophosphoramidate (DMMPA) have been assessed in rabbits for dermal application and in rats for parenteral application. One hundred day application of DMMPA dermally to rabbits was without effect. One hundred day application to rats, both male and female, was without effect on breeding both in the incidence of pregnancies, number of pups per litter and the number of still-born. Three separate experiments are described in which male and female rats were dosed with DMMPA in periods from 100 to 240 days. Some thirty separate pathological screening tests were examined including nutritional, physiological, haematological, blood chemistry, tissue weight and water content procedures as well as macroscopic and microscopic pathology. Tests done with rabbits and rats.
Report Number
TP-467 —
Date of publication
15 Aug 1977
Number of Pages
75
DSTKIM No
77-03998
CANDIS No
100684
Format(s):
Hardcopy;Originator's fiche received by DSIS

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