DIMINISHING RADIATION DAMAGE AND ENHANCING IMMUME SYSTEM RECOVERY - A STUDY

Authors
  1. Roy, R.M.
Corporate Authors
Concordia Univ, Montreal QUE (CAN) Dept of Biology;Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The modifying effects of seven compounds (tocopherol, lipoic acid, lithium carbonate, nicotinamide, 3-aminobenzamide, splenic lymphocytes) at various concentractions, times and in combinations have damage and recovery: (1) radiation-induced interphase death, (2) proliferative response to mitogens, (3) repair of sub-lethal damage, (4) humoral immune response to sheep and (5) cell-mediated immune response. For interphase death, tocopherol, lithium carbonate and lipoic acid were clearly effective in reducing lethality when administered from zero to 12 hours after irradiation. Combinations were not much more effective.
Date of publication
15 Mar 1991
Number of Pages
31
DSTKIM No
92-00026
CANDIS No
102928
Format(s):
Hardcopy;Originator's fiche received by DSIS

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