Partition Coefficients of some Morphines, Morphinans and Benzomorphans in Ether-Water and 1-Octonal-Water

Authors
  1. Holmes, H.L.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Partition coefficients of a number of morphines and codeines and their derivatives have been calculated by the method previously described and these compared favorably with the observed values. The effect of conformation and hydrogen bonding upon partition coefficient has been examined. In the cases examined conformation of the molecule has more effect upon the partition coefficient than does the basicity of the molecule.
Report Number
DRES-TP-373 — Technical Paper
Date of publication
15 Jun 1971
Number of Pages
23
DSTKIM No
71-05205
CANDIS No
10305
Format(s):
Hardcopy;Originator's fiche received by DSIS

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