RECEPTOR DEVELOPMENT FOR AN ELECTROCHEMICAL LIPID MEMBRANE BIOSENSOR

Authors
  1. Krull, U.J.
  2. Thompson, M.
  3. Vigmond, S.
  4. Brown, R.S.
  5. McGibbon, E.T.
  6. and others
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Chemistry
Abstract
Selective receptor chemistry for an electrochemical biosensor based on transduction by perturbation of a lipid membrane by a selective binding agent will be developed. The selective binding agents used to achieve chemical transduction will be natural acetylcholine receptor, and synthetic receptor. These will be designed to optimize the perturbation of the physical and electrostatic structure of the membrane when selective binding occurs. Methods to achieve binding system reversibility will be investigated for all the proposed receptors.
Report Number
DRES-CR-45-91 — Contract Report
Date of publication
15 Apr 1991
Number of Pages
254
DSTKIM No
92-00444
CANDIS No
103342
Format(s):
Hardcopy;Originator's fiche received by DSIS

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