THE ANTICHOLINESTERASE ACTIVITY OF ORGANOPHOSPHATE NERVE AGENTS IN PRIMARY CULTURES OF CHICK EMBRYO FOREBRAIN NEURONS

Authors
  1. Sawyer, T.W.
  2. Weiss, M.T.
  3. Unger, R.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Primary cultures of chick embryo forebrain neurons were examined with respect to their usefulness as indicators of the relative anticholinesterase activities of organophosphate nerve agents. The median inhibitory concentrations (IC50s) of these agents with respect to acetylcholinesterase activity, closely paralleled those previously reported in mouse embryo cortical neuron cultures. In addition, the chick embryo neuron system offered several advantages over mouse neuron cultures, while still maintaining the capacity to predict the potential toxicity of these nerve agents in vivo.
Report Number
DRES-M-1309 — Memorandum
Date of publication
15 Nov 1991
Number of Pages
24
DSTKIM No
92-00548
CANDIS No
103445
Format(s):
Hardcopy;Originator's fiche received by DSIS

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