ASSESSMENT OF THE POSSIBLE CARCINOGENICITY OF HI-6

Authors
  1. Nestmann, E.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);CanTox Inc, Mississauga ONT (CAN)
Abstract
HI-6 is a new member of a group of bispyridinium oximes which are used as antidotes to nerve gas poisoning. This is an important compound since it is the most potent cholinesterase reactivator in the group and is active against soman, a nerve gas whose activity is not diminished by other antidotes. Several in vitro tests have been carried out to define the genotoxic potential of HI-6. The purpose of this report is to review the findings of these studies and to discuss their application to the assessment of the carcinogenicity of HI-6. The application of genotoxicity data to the predicton of carcinogenicity is discussed, based on a review of the literature. To put the genotoxicity results into perspective with respect to results of similar tests with other compounds, four compounds which exhibit genotoxic potential, but which do not cause undue health risks for humans are discussed. TRUNCATED
Report Number
DRES-CR-07-92 —
Date of publication
15 Nov 1991
Number of Pages
65
DSTKIM No
92-00639
CANDIS No
103533
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: