LIPID METABOLISM IN COLD-EXPOSED HUMANS; SOURCE OF FATTY ACIDS OXIDIZED DURING SHIVERING THERMOGENESIS

Authors
  1. Vallerand, A.L.
  2. Jacobs, I.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The goal of the study was to determine the changes in lipid utilization associated with cold exposure in humans, and whether plasma triglyceride (TG) and lipolysis play an important role in lipid metabolism during cold exposure. This was achieved by: calculating the rates of substrate oxidation from indirect calorimetry, by performing an intravenous fat tolerance test (IVFTT; an index of plasma TG utilization) and by measuring changes in plasma glycerol levels (an index of lipolysis). Since fat clearance is increased 24 h after exercise, a second cold exposure combined with an IVFTT were also performed 24 h after the first cold exposure, to evaluate the possibility of a delayed increase in fat tolerance. Six healthy males were therefore subjected to an IVFTT (1 ml/kg 10% Intralipid) on 3 occasions (fasting semi-nude) while resting for 160 min: (1) at thermal neutrality (29C), (2) in the cold (10C, 1 m/s wind) and (3) in the cold 24 h after the first cold test. TRUNCATED
Report Number
DCIEM-91-P-22 — Research Paper; Reprint
Date of publication
01 Jan 1990
Number of Pages
8
Reprinted from
Metabolism, vol 39, no 11, 1990, p 1211-1218
DSTKIM No
92-00973
CANDIS No
103866
Format(s):
Hardcopy;Originator's fiche received by DSIS

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