DETECTION AND IDENTIFICATION OF HUMAN INFLUENZA VIRUSES BY THE POLYMERASE CHAIN REACTION

Authors
  1. Evans, D.H.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Guelph Univ, Guelph ONT (CAN) Dept of Molecular Biology and Genetics
Abstract
Three distinct types of viruses have been classified as belonging to the orthomyxovirus group of viruses. Clinically the A and B types are the most important and consequently research has focused on these two viruses. This is reflected in the sequence data-bases where only limited cDNA sequence information is available for the type C viruses. All three viruses share common structural features such as inverted-complementary segment ends and multipartite genomes. Types A and B are composed of 8 minus-strand RNA segments and type C contain 7 segments. The encoded proteins are functionally conserved between types with types A and B being more closely related to each other than to type C. Type C viruses lack a distinct neuraminidase activity which may account for the missing segment.
Report Number
DRES-CR-18-92 — Contract Report (Interim); Technical Report
Date of publication
01 Jan 1992
Number of Pages
196
DSTKIM No
92-01585
CANDIS No
104475
Format(s):
Hardcopy;Originator's fiche received by DSIS

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