RATE OF FORMATION OF CARBOXYHEMOGLOBIN IN EXERCISING HUMANS EXPOSED TO CARBON MONOXIDE

Authors
  1. Tikuisis, P.
  2. Kane, D.M.
  3. McLellan, T.M.
  4. Buick, F.
  5. Fairburn, S.M.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The purpose of the study was to test the CFK equation for its prediction of the rate of formation of carboxyhemoglobin (HbCO) in exercising humans by use of measured values of the respiratory variables and to characterize the rate of appearance of HbCO with frequent blood sampling. Ten nonsmoking male subjects were exposed to carbon monoxide (CO) on two separate occasions distinguished by the level of activity. Steady-state exercise was conducted on a cycle ergometer at either a low (approximately equals to 45W) or moderate (approximately equals to 90 W) power output. Each experiment began with an exposure of 3,000 ppm CO for 3 min during a rest period followed by three intermitent exposures ranging from 3,000 ppm CO for 1 min at low exercise to 667 ppm CO for 3 min at moderate exercise. Increases in HbCO were normalized against predicted values to account for individual differences in the variables that govern CO uptake. TRUNCATED
Report Number
DCIEM-90-55 — Reprint
Date of publication
15 Oct 1991
Number of Pages
9
Reprinted from
J Appl Physiol, vol 72, no 4, 1992, p 1311-1319
DSTKIM No
92-01744
CANDIS No
104630
Format(s):
Hardcopy

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