INVESTIGATION OF ANTI-MOTION SICKNESS DRUGS IN THE SQUIRREL MONKEY

Authors
  1. Cheung, B.S.K.
  2. Money, K.E.
  3. Kohl, R.L.
  4. Kinter, L.B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Early attempts to develop an animal model for anti-motion sickness drugs, using dogs and cats, were unsuccessful. Dogs did not show a beneficial effect of scopolamine (probably the best single anti-motion sickness drug for humans thus far) and the findings in cats were not definitive. The authors have developed an animal model using the squirrel monkey (Saimiri sciureus) of the Bolivian phenotype. Unrestrained monkeys in a small lucite cage were tested in an apparatus that induces motion sickness by combining vertical oscillation and horizontal rotation in a visually unrestricted laboratory environment. Signs of motion sickness were scored using a rating scale. Ten susceptible monkeys (weighing 800-1000 g) were given a total of five tests each, to establish the baseline susceptibilty level. TRUNCATED
Report Number
DCIEM-91-09 — Reprint
Date of publication
15 Feb 1992
Number of Pages
13
Reprinted from
J of Clinical Pharmacology, vol 32, no 2, 1992, p 163-175
DSTKIM No
92-01767
CANDIS No
104653
Format(s):
Hardcopy;Originator's fiche received by DSIS

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