BINDING OF THE BISPYRIDINIUM OXIME, HI-6, TO DNA

Authors
  1. Lee, W.E.
  2. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
A study of the in vitro binding of the bispyridinium oxime, HI-6, to calf thymus DNA was undertaken by elution of mixed solutions of 14C-labelled HI-6 and DNA through columns of size exclusion gel, Sephadex G-25. From a comparison of the elution profiles of mixed solutions with those of the components, 14C HI-6 and DNA, the results of the study indicated that HI-6 does not bind to DNA in vitro and suggests that the interaction of HI-6 with cellular DNA in vivo would also be very low.
Report Number
DRES-M-1377 — Memorandum
Date of publication
15 Mar 1992
Number of Pages
19
DSTKIM No
92-01885
CANDIS No
104770
Format(s):
Hardcopy;Originator's fiche received by DSIS

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