REACTIVE SKIN DECONTAMINANT REACTIVITY STUDIES: THE EFFECT OF O-ACETYL 2,3-BUTANEDIONE MONOOXIME ON THE STABILITY OF 2,3-BUTANEDIONE MONOOXIMATE
- Authors
- Corporate Authors
- Defence Research Establishment Suffield, Ralston ALTA (CAN)
- Abstract
- The reaction of acetic anhydride with 2,3-butanedione monooximate, to generate in situ O-acetyl 2,3-butanedione monooxime, has been examined in four solvents. In water, the initially formed O-acetyl oxime undergoes a general-base catalysed Beckmann rearrangement; if present in excess, one equivalent of oximate is consumed by every equivalent of acetic anhydride. In acetonitrile, O-acetyl 2,3-butanedione monooxime catalyses the disproportionation of 2,3-butanedione monooximate. In RSD formulations employing polyethylene glycol monomethyl ether of average molecular weight 550 (MPEG-550) and 10% w/w water/MPEG-550 less than one equivalent of oximate is consumed by every equivalent of acetic anhydride. While O-acetyl 2,3-butanedione monooxime catalysed disproportionation of 2,3-butanedione monooximate does not occur in the medium employed for the RSD, it may place a significant constraint on the use of this nucleophile in decontaminants which employ aprotic media.
- Report Number
- DRES-M-1382 — Memorandum
- Date of publication
- 15 Mar 1992
- Number of Pages
- 17
- DSTKIM No
- 92-01887
- CANDIS No
- 104772
- Format(s):
- Document Image stored on Optical Disk;Originator's fiche received by DSIS
Document 1 of 1
- Date modified: