CLAM POISON II: PURIFICATION OF CLAM POISON RESIDUES OF LOW TOXICITY BY A HEAVY-PAPER TECHNIQUE

Authors
  1. Bannard, R.A.B.
  2. Casselman, A.A.
Corporate Authors
Defence Research Chemical Labs, Ottawa ONT (CAN)
Abstract
The usefulness of Whatman seed-test and No. 17 papers has been examined for purification and recovery on a preparative scale of the toxin present in residues of low toxicity from the Schantz alumina chromatographic method for purification of clam poison. A method was developed to minimize introduction of impurities from the papers into fractions recovered after chromatography when t-butanol:acetic acid:water (2:1:1) was used as developer. The paper chromatographic properties, toxicity, and infrared spectrum of the recovered poison agree with those reported by Schantz and co-workers for pure clam poison dihydrochloride, but the specific rotation is lower by 25%. Four possible alternative explanations for the observed anomalous rotation are discussed.
Report Number
DRCL-346A — Reprint; Previously accessioned as DSIS 61/18344; See also DSIS 92-02260
Date of publication
01 Jan 1961
Number of Pages
10
Reprinted from
Canadian J of Chemistry, vol 39, 1961, p 1879-1887
DSTKIM No
92-02259
CANDIS No
105143
Format(s):
Hardcopy;Originator's fiche received by DSIS

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