NITROFURANTOIN-INDUCED PULMONARY TOXICITY: IN VIVO EVIDENCE FOR OXIDATIVE STRESS-MEDIATED MECHANISMS

Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The present study was carried out to examine whether nitrofurantoin-induced pulmonary toxicity in normal rats was mediated via oxidant stress mechanisms. The relative importance of the cellular antioxidant enzymes in nitrofurantoin toxicity was also assessed. For this, the pulmonary toxicity induced by nitrofurantoin in rats was evaluated at various time intervals after a single subcutaneous injection. Data from this study showed that nitrofurantoin (200 mg/kg, sc) resulted in transient but measurable lung damage as evidenced by the increases in wet lung weight/body weight ratio and decreases in lung angiotensin converting enzyme activity. A transient decrease in GSH concentrations with a concurrent increase in GSSG concentrations as well as an increase in lipid peroxidation levels (measured by the formation of diene conjugates and thiobarbituric acid reactants) were also evident in lungs of nitrofurantoin-treated rats. TRUNCATED
Report Number
DCIEM-91-51 — Research Paper; Reprint
Date of publication
15 Oct 1991
Number of Pages
9
Reprinted from
Biochemical Pharmacology, vol 43, no 5, 1992, p 1127-1135
DSTKIM No
92-02425
CANDIS No
105300
Format(s):
Hardcopy;Originator's fiche received by DSIS

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