INVESTIGATION OF T-2 MYCOTOXIN-INDUCED CYTOTOXICITY IN VITRO AND PROTECTIVE EFFECTS OF FLAVONOID COMPOUNDS

Authors
  1. Markham, R.J.F.
  2. Dininno,V.L.
  3. Erhardt, N.P.
  4. Peman,D.
  5. Bhatti, A.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Aspects of the in vitro cytotoxic effects of T-2 mycotoxin on murine thymocytes were investigated. Cytotoxicity was found to be consistent when tested bi-weekly for a four month period. Cytotoxicity was found to be consistent when over a narrow range of doses and was dependent on temperature (37 C optimum) and number of cells in the reaction mixtures. Quecertin, a flavonoid compound was able to decrease the effect of T-2 toxin when the drug was added within an hour of mixing of T-2 toxin with the thymocytes.
Report Number
M-1150 —
Date of publication
15 Jan 1986
Number of Pages
25
DSTKIM No
86-00527
CANDIS No
106148
Format(s):
Hardcopy;Originator's fiche received by DSIS

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