MODELLING THE UPTAKE OF INERT GAS IN ANESTHETIZED RABBITS UNDER HYPERBARIC CONDITIONS

Authors
  1. Tikuisis, P.
  2. Nishi, R.Y.
  3. Giry, P.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The rate of uptake of inert gas was modelled mathematically to analyze the measured uptake of He and N2 in the arterial and mixed venous blood of anesthetized rabbits under hyperbaric conditions. These gases were breathed separately and switched isobarically, and were measured in vivo with a fast response mass spectrometer probe. Various compartmental models were applied to analyze the rate of inert gas uptake in the rabbit. The one-compartment model suggested that the uptake of N2 in the whole body was perfusion-limited; however, this was not the case for He uptake. When a two-compartment model of fat and non-fat components was applied, the prediction of the fat composion of the rabbit was found to be unrealistically high. A four-compartment perfusion-limited model, which included the alveolar region, greatly overpredicted the saturation rates for both He and N2 in blood. TRUNCATED
Report Number
85-R-50 —
Date of publication
15 Dec 1985
Number of Pages
22
DSTKIM No
86-00700
CANDIS No
106317
Format(s):
Hardcopy;Originator's fiche received by DSIS

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