THE SYNERGISTIC ACTION OF 2-(o-CRESYL)-4H-1:3:2-BENZODIOXAPHOSPHORIN-2-OXIDE WITH GD AND PHYSOSTIGMINE

Authors
  1. McKay, D.H.
  2. Jardine, R.V.
  3. Adie, P.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The synergism which has been reported between tri-o-cresyl phosphate (TOCP) and anticholinesterase inhibitors has been extended to the cyclic metabolite of TOCP, 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP). This metabolite has been examined using a reversible inhibitor physostigmine, and a non-reversible inhibitor GD. Studies carried out on male white mice revealed that at doses of 35 mg/kg CBDP the activity of GD was enhanced over eighteen-fold, while that of physostigmine was somewhat less than two-fold. This has been attributed to the fact that the reversible quality of physostigmine allows a general distribution throughout various enzyme sites, thus reducing the amount of bound agent. This is in contrast to the specific and irreversible reaction of GD with acetylcholinesterase.
Report Number
DRES-TN-280 — Technical Note
Date of publication
15 Jul 1971
Number of Pages
15
DSTKIM No
71-07115
CANDIS No
11100
Format(s):
Hardcopy;Originator's fiche received by DSIS

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