MECHANISM OF THE CARDIOVASCULAR ACTIVITY OF DIBENZ (b,f)(1,4) OXAZEPINE (CR) IN CATS

Authors
  1. Lundy, P.M.
  2. McKay, D.H.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Dibenz(b,f)(1,4)oxazepine (CR) is a potent irritant of skin, eyes and throat of man. It is absorbed readily through the lungs and probably the skin of experimental animals. Humans exposed to the compound respond with increased blood pressure and heart rate of unknown etiology. Cats injected with 50-200 mug/kg dibenzoxazepine, I.V., respond with increased heart rate (40-50%) and blood pressure (up to 60%). The results suggest that the cardiovascular stimulation seen following small doses of dibenzoxazepine was due to activation of the sympathetic nervous system.
Report Number
TP-438 —
Date of publication
15 Sep 1975
Number of Pages
30
DSTKIM No
76-00886
CANDIS No
117745
Format(s):
Hardcopy;Originator's fiche received by DSIS

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