HI-6: A COMPARATIVE STUDY OF VARIOUS SAMPLES

Authors
  1. Clement, J.G.
  2. Lockwood, P.A.
  3. Thompson, H.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
A comparison of the chemical purity, toxicology and efficacy of HI-6 ([[[4-(aminocarbonyl)pyridino]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dichloride) obtained from various sources was performed. There were no significant differences between HI-6 obtained from either Israel, Yugoslavia, The Netherlands or Canada regarding their efficacy, when combined with atropine, as an antidote of organophosphate poisoning. HI-6 obtained from Great Britain was significantly more toxic and less efficacious than any of the other HI-6 samples. In addition the results of this study showed that there was no significant difference between HI-6 prepared as a laboratory batch and HI-6 prepared commercially with regards to chemical purity, toxicology or efficacy.
Report Number
380 —
Date of publication
15 Dec 1983
Number of Pages
15
DSTKIM No
84-01298
CANDIS No
120742
Format(s):
Hardcopy;Originator's fiche received by DSIS

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