THE EFFECTS OF POSITIVE PRESSURE BREATHING WITH POSITIVE END-EXPIRATORY PRESSURE (PEEP) ON CARDIAC OUTPUT AND BLOOD PRESSURE IN DOGS - A POSSIBLE ROLE FOR THE PROSTAGLANDINS

Authors
  1. Young, E.R.
  2. Sunahara, F.
  3. Porlier, G.
Corporate Authors
Toronto Univ, Toronto ONT (CAN) Dept of Pharmacology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The influence of indomethacin and counterpressurization on the cardiovascular responses of anaesthetized mechanically ventilated dogs subjected to intervals of PEEP 10 and 20 mmHg were studied. Animals treated with indomethacin were better able to withstand both PEEP levels in that cardiac output and blood pressure were maintained better than nontreated dogs subjected to similar levels PEEP. Application of simultaneous counterpressurization resulted in less blood pressure drop although cardiac output was not significantly improved. Both regimes permitted more rapid recovery of cardiovascular parameters to baseline values with removal of PEEP. These results support the hypothesis that hyperexpansion of the lung during PEEP may increase the release of cardiodepressant and/or vasodilator prostaglandins. TRUNCATED
Date of publication
01 Jan 1983
Number of Pages
256
DSTKIM No
84-02074
CANDIS No
121464
Format(s):
Originator's fiche received by DSIS;Hardcopy

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