ALTERATIONS OF APOMORPHINE INDUCED STEREOTYPED REARING BY HYPERBARIC AIR

Authors
  1. Johnston, J.P.
  2. Philp, R.
Corporate Authors
University of Western Ontario, London ONT (CAN) Dept of Pharmacology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The mechanisms involved in the interaction between centrally acting drugs and the hyperbaric environment was investigated. A specific dopaminergic agonist, apomorphine, and a behavioural index, namely the stereotyped rearing response, was used to determine the effect of hyperbaric air on dopaminergic systems. The results of the behavioural studies indicate that pressure has a differential effect on apomorphine-induced stereotyped rearing, depending upon the dose of the drug, and the pressure at which it is tested. Analysis of apomorphine levels in blood and brain samples indicated that no change in the distribution of apomorphine occurred under pressure. These studies have shown that increased pressures of air are capable of altering the functioning of specific transmitter systems. It is difficult, however, to establish which particular aspect of dopaminergic transmission is affected by pressure.
Date of publication
15 Sep 1983
Number of Pages
147
DSTKIM No
84-02105
CANDIS No
121495
Format(s):
Originator's fiche received by DSIS;Hardcopy

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