PREVENTION OF THE ENHANCING EFFECT OF MUCIN AND IRON IN MOUSE MENINGOCOCCAL INFECTION

Authors
  1. Dupuy, J.M.
  2. Sparkes, B.G.
  3. Desrosiers, M.
  4. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
In vivo resistance of mice to Neisseria meningitidis was entirely abrogated by a concomitant administration of mucin and iron with N. meningitidis organisms. Resistance, however, was restored when the latter challenge was given to animals which had been immunized 7 days previously with a crude extract of meningococal antigens (MA), BCG, or proteose peptone. These results suggest that depression or activation of the reticuloendothelial system (RES) may be important in resistant of mice to meningococcal infection. Also, like BCG, MA inoculation was able to prevent infection by Listeria monocytogenes indicating its marked ability to activate the RES. The data show that immunization can induce nonspecific RES stimulation and that the nonspecific resistance persists for at least 7 days.
Report Number
83-P-45 — Research Paper
Date of publication
01 Jan 1983
Number of Pages
4
Reprinted from
Canadian J of Microbiology, vol 29, no 12, 1983, p 1671-1674
DSTKIM No
84-02540
CANDIS No
121923
Format(s):
Originator's fiche received by DSIS;Hardcopy

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