DUAL EFFECT OF MENINGOCOCCAL ANTIGENS ON A T CELL DEPENDENT IMMUNE RESPONSE

Authors
  1. Sparkes, B.G.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Meningococcal antigens (MA) showed adjuvant activity when administered to mice at the same time as antigen (sheep erythrocyte (SE)), by increasing the splenocyte plaque-forming response in a dose-related manner. However, when SE were given 1 day after MA administration, the subsequent plaque formation was diminished from normal in proportion to the dose of MA injected. Splenocytes taken from mice up to 5 days after MA injection actively inhibited plaque formation when mixed with splenocytes immunized with SE 4 days earlier. Two days after MA injection the nonspecific inhibition of plaque formation was mainly due to adherent spleen cells, while at 5 days nonadherent cells had acquired the inhibitory activity. It appears that it is the degree of activation of adherent cells resulting from the timing and dosage of MA which modulates the subsequent development and secretion of antibody-forming cells.
Report Number
83-P-43 — Research Paper
Date of publication
01 Jan 1983
Number of Pages
7
Reprinted from
Canadian J of Microbiology, vol 29, no 12, 1983, p 1619-1625
DSTKIM No
84-02541
CANDIS No
121924
Format(s):
Originator's fiche received by DSIS;Hardcopy

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