IMMUNOMODULATING ACTIVITY OF MENINGOCOCCAL ANTIGENS

Authors
  1. Sparkes, B.G.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
A preparation of meningococcal antigens (MA) extracted in CaCl2, and containing mostly outer membrane proteins, was strongly mitogenic for murine B lymphocytes. Given to mice in vitro, MA markedly impaired subsequent in vitro T-cell responses of splenocytes. Supression of normal T splenocytes in vitro occurred with both adherent (Ad) and nonadherent (NA) splenocytes from MA-sensitized mice. B cells were much less affected by the suppression induced by MA, and only Ad cells could convey in vitro the low level impairment of B-cell proliferation. Strong T-cell suppression associated with a B-cell mitogen is also produced by bacillus Calmette-Guerin (BCG) and Corynebacterium parvum. The possible role of these phenomena in meningococcal disease is discussed.
Report Number
83-P-42 — Research Paper
Date of publication
01 Jan 1983
Number of Pages
8
Reprinted from
Canadian J of Microbiology, vol 29, no 12, 1983, p 1611-1618
DSTKIM No
84-02542
CANDIS No
121925
Format(s):
Originator's fiche received by DSIS;Hardcopy

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