MOUSE IMMUNE RESPONSE TO MENINGOCOCCAL ANTIGENS

Authors
  1. Micusan, V.V.
  2. Bisaillon, J.G.
  3. Sparkes, B.G.
  4. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The mouse immune response against Neisseria meningitidis was studied by using an extract from group Y (Slaterus) known to contain protein antigens common to other meningococci. By using a solid-phase radioimmunoassay, high titers of specific IgM and IgG class antibodies were measured which lasted over 2 months after immunization. These antibodies cross-reacted with similar extracts from other meningococci groups. Bactericidal antibodies directed against protein antigens were also elicited after immunization and they belonged to IgM, IgG2a, and IgG2b isotypes. Cellular immunity, expressed as delayed type hypersensitivity under the conditions tested, could be detected neither in homologous nor heterologous reactions.
Report Number
83-P-41 — Research Paper
Date of publication
01 Jan 1983
Number of Pages
8
Reprinted from
Canadian J of Microbiology, vol 29, no 10, 1983, p 1323-1330
DSTKIM No
84-02543
CANDIS No
121926
Format(s):
Originator's fiche received by DSIS;Hardcopy

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