THE EFFECT OF VASODILATOR DRUGS (RONIACOL AND PRISCOLINE) ON SKIN TEMPERATURES AND BLOOD FLOW DURING MILD COLD STRESS

Authors
  1. Myles, W.S.
  2. Livingstone, S.D.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Two vasodilator drugs (Roniacol and Priscoline) were tested for their potential prophylactic effect in the prevention of cold-induced vasoconstriction in the hands of human subjects during exposure to mild cold stress. The drugs were administered as a single dose by mouth (300 mg Roniacol or 50 mg Priscoline) to nude subjects lying quietly for 90 minutes at 21C. Skin temperatures were measured at the left middle finger, the left big toe and the abdomen, also, skin blood flow in the right middle finger was monitored. Neither Roniacol nor Priscoline had any effect on these measurements of skin temperature or skin blood flow as compared to similar measurements made in control (no drug) exposures. Truncated
Report Number
TR-77-X-7 —
Date of publication
15 Feb 1977
Number of Pages
9
DSTKIM No
77-02157
CANDIS No
125187
Format(s):
Hardcopy;Originator's fiche received by DSIS

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