MECHANISMS OF IMMUNE FAILURE IN BURN INJURY

PDF

Authors
  1. Sparkes, B.G.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The burden on military medical services in handling burn casualties is daunting as all physiological systems will become affected. Severe burns in a battlefield setting have a very low salvage rate, to a great degree because of the immune failure which invariably develops. Evaluations of responses of lymphocytes taken from burn patients over several weeks following the burn (> 30% TBSA), have revealed that the immune failure which follows thermal injury involves T cell activation events. Interleukin 2, which is normally produced by activated T lymphocytes, is very poorly produced by cells cultivated in vitro taken from non-surviving patients, whereas some production continues, although at below normal levels, in patients who ultimately survive their injury.
Report Number
AGARD-CP-518-PAP-2 — @Paper presented at the AGARD Aerospace Medical Panel Symposium, Rome, Italy, 21-25 October 1991; CONTAINED IN 92-03430
Date of publication
15 Apr 1992
Number of Pages
14
DSTKIM No
92-03429
CANDIS No
125868
Format(s):
Hardcopy;Document Image stored on Optical Disk

Permanent link

Document 1 of 1

Date modified: