PRODROMAL EFFECTS OF RADIATION: PATHWAYS, MODELS, AND PROTECTION BY ANTIEMETICS

Authors
  1. Harding, R.K.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The prodromal effects of radiation injury are characterized by nausea, vomiting, and malaise (fatigue, anorexia). The effects are typically present in the second hour postirradiation. The threshold for vomiting in humans is approximately 1 Gy (large volume irradiation). The vomiting usually stops within several hours. It is generally accepted that as the dose of irradiation increases, so too does the incidence of emesis; however, while an ED50 may be calculated for humans there is no ED100. Research in monkeys has shown that with high doses of irradiation (> 10 Gy) the incidence of vomiting decreases; with increasing doses, frank behavioral incapacitation is seen in some of these animals. Such global central nervous system (CNS) depression may explain the diminished capacity to perform a complex activity such as vomiting.
Date of publication
01 Jan 1988
Number of Pages
11
Reprinted from
Pharmac Ther, vol 39, 1988, p 335-345
DSTKIM No
92-03463
CANDIS No
125899
Format(s):
Hardcopy;Originator's fiche received by DSIS

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