THE EFFECT OF CAPTOPRIL ON +Gz TOLERANCE OF NORMOTENSIVES

Authors
  1. Paul, M.A.
  2. Gray, G.W.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Recently, there has been considerable interest in whether angiotensin converting enzyme inhibitors can be used to treat hypertensive pilots without compromising their operational effectiveness. This study was undertaken to evaluate the possible effects of captopril on tolerance to +Gz, of relevance in tactical fighter operations. A counterbalanced double blind crossover protocol was used to administer 25 mg of captopril or placebo twice daily in identical capsules to seven fit, normotensive individuals from the DCIEM acceleration research panel. The five males and two females took each course of capsules for 4 d prior to G-tolerance assessment and waited 1 week for drug wash-out after assessment on their first condition prior to commencement of the second course of capsules. The subjects did not wear G-suits. Standard ASCC gradual onset runs, relaxed and with a straining maneuver, and rapid onset runs were used to assess G tolerance.
Report Number
DCIEM-91-42 — Reprint
Date of publication
15 Aug 1992
Number of Pages
3
Reprinted from
Aviat Space Environ Med, vol 63, 1992, p 706-708
DSTKIM No
92-03474
CANDIS No
125908
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: