RADIATION CATARACTOGENESIS INDUCED BY NEUTRON OR GAMMA IRRADIATION IN THE RAT LENS IS REDUCED BY VITAMIN E

Authors
  1. Ross, W.M.
  2. Creighton, M.O.
  3. Trevithick, J.R.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN);University of Western Ontario, London ONT (CAN) Dept of Ophthalmology;University of Western Ontario, London ONT (CAN) Dept of Biochemistry
Abstract
Although cataract of the eye lens is a known late effect of ionizing radiation exposure, most of the experimental work to date has concentrated on single, acute high doses or multiple, fractionated, chronic exposures. Many papers have dealt with biochemical alterations in metabolism and cellular components, with microscopic and electron microscopic lesions to the epithelial and cortical layers, and with clinical cataract formation. Our purpose in designing this pilot study was three fold: firstly, to determine whether any physical damage could be detected after low, acute exposure to neutron radiation (10 and 100 cGy); secondly, to compare the relative effectiveness of fast (14 MeV) neutrons with gamma-rays; and thirdly, to investigate the possibility that vitamin E could protect the lenses from radiation damage.
Date of publication
15 Jul 1990
Number of Pages
10
Reprinted from
Scanning Microscopy, vol 4, no 3, 1990, p 641-650
DSTKIM No
92-03436
CANDIS No
125993
Format(s):
Hardcopy;Originator's fiche received by DSIS

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