THE RADIOPROTECTIVE AND THERAPEUTIC EFFECTS OF IMIDAZOLE AND ERYTHROPOIETIN ON THE ERYTHROPOIESIS AND SURVIVAL OF IRRADIATED MICE

Authors
  1. Vittorio, P.V.
  2. Whitfield, J.F.
  3. Rixon, R.H.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The results showed that imidazole increased the survival of irradiated mice when administered 4.5 hours before irradiation, 5 minutes before irradiation, or immediately after irradiation. The highest reduction of radiation lethality was obtained when imidazole was administered 5 minutes before irradiation. When the pre- or post- irradiation imidazole treatment was combined with a postirradiation administration of erythropoietin, there was a further increase in both erythropoiesis and survival.
Report Number
639 —
Date of publication
01 Jan 1971
Number of Pages
8
Reprinted from
Radiation Research, vol 47, no 1, 1971, p191-198
DSTKIM No
72-00565
CANDIS No
12614
Format(s):
Hardcopy;Originator's fiche received by DSIS

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