AN ENZYMATIC EVALUATION OF THIOL RADIOPROTECTORS

Authors
  1. Scaife, J.F.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
Thiol and disulfide compounds have been tested for their ability to inhibit the oxidation of alpha-ketoglutarate by rat-liver homogenates. A correlation exists between the degree of inhibition and the radioprotective ability of the compound. It is possible that a better correlation exists for the corresponding disulfides. The inhibition involves oxidation of the thiol, and the disulfides were found to be more potent inhibitors than the thiols. The results support the mixed disulfide protection theory of Eldjarn and Pihl, and provide a physiologically significant test system for this hypothesis.
Report Number
DCBRL-477 — Reprint; Previously accessioned as DSIS 66-04924
Date of publication
15 Aug 1965
Number of Pages
13
Reprinted from
Canadian J of Biochemistry, vol 44, 1966, p 319-330
DSTKIM No
92-03623
CANDIS No
126982
Format(s):
Hardcopy;Originator's fiche received by DSIS

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