PREPARATION AND TOXICITY OF SOME ALKYL THIOPYROPHOSPHATES (paper presented in part at the Association canadienne-francaise pour l'avancement des sciences conference, (24th), 3 November 1956)

Authors
  1. McIvor, R.A.
  2. McCarthy, G.D.
  3. Grant, G.A.
Corporate Authors
Defence Research Chemical Labs, Ottawa ONT (CAN)
Abstract
Several methods have been investigated for the synthesis of tetraalkyl thiopyrophosphates, including one that can be carried out very rapidly with high yield. Purification of these compounds proved exceedingly difficult, because they were sensitive to traces of acids or bases, and probably to inorganic salts at temperatures above 70C. All methods investigated yield only the thiono isomer, there being no evidence for the corresponding P-S-P isomer. Toxicological studies do not support the results reported by Fiszer and workers. None of the compounds is more toxic intravenously than tetraethyl pyrophosphate. The synthesis of several other related compounds for infrared study is reported.
Report Number
DRCL-201A — Reprint; Previously accessioned as DSIS 57/01425
Date of publication
15 Aug 1956
Number of Pages
15
Reprinted from
Canadian J of Chemistry, vol 34, 1956, p 1819-1832
DSTKIM No
92-03661
CANDIS No
127014
Format(s):
Hardcopy;Originator's fiche received by DSIS

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