CHROMATOGRAPHIC SEPARATION OF THE 1-METHOXY-2(3)-HYDROXY-3(2)-BROMOCYCLOHEXANES AND THEIR DERIVATIVES

Authors
  1. Casselman, A.A.
  2. Bannard, R.A.B.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
During the characterization of the mixture of positionally isomeric and stereoisomeric bromohydrins resulting from the action of aqueous N-bromosuccinimide upon 1-methoxycyclohexene-2 super1-3, difficulty was encountered in the separation of the primary products, their acetates, 1-naphthylurethanes, deetherification products, and their diacetates by the conventional methods of distillation and crystallization. Microchemical analysis fails to establish the absence of contamination of a compound by one or more of its isomers and it is frequently difficult to detect small quantities of such undesirable impurities by physical methods such as infrared spectral analysis. In an effort to find a suitable method for the separation of these isomers and to provide reliable criteria for their homogeneity, paper, thin-layer, and vapor phase chromatographic methods were examined and a summary of the results obtained is presented in Table I.
Report Number
DCBRL-463 — Reprint; Previously accessioned as DSIS 66-03786
Date of publication
15 May 1965
Number of Pages
6
Reprinted from
J of Chromatography, vol 20, 1965, p 424-428
DSTKIM No
92-03733
CANDIS No
127083
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: