THE USE OF Cr51 AS A CRITERION OF THYMOCYTE REGENERATION AFTER WHOLE BODY X-IRRADIATION

Authors
  1. Vittorio, P.V.
  2. Baker, P.J.
  3. Dziubalo-Blehm, S.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
The uptake of Cr51 chromate by thymocytes in vitro after whole body X-irradiation can be used as a sensitive quantitative criterion not only for the evaluation of early radiation damage to these cells but also as a measure of later regeneration. The effect of different doses of X-irradiation on the regeneration of thymocytes has been demonstrated. Treatment with AET before whole body X-irradiation (400 r) indicated that less regeneration was necessary but the recovery time remained unchanged. Age differences produced a change in the extent of repair or regeneration but no change in recovery time. Spermatozoa showed evidence of early damage after whole body X-irradiation. This damage increased with time with no evidence of increased regeneration or repair.
Report Number
DCBRL-441 — Reprint; Previously accessioned as DSIS 65-02674
Date of publication
15 Aug 1964
Number of Pages
10
Reprinted from
Canadian J of Physiology and Pharmacology, vol 43, 1965, p 19-27
DSTKIM No
92-03836
CANDIS No
127169
Format(s):
Hardcopy;Originator's fiche received by DSIS

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