CHOLINOLYTICS IN THE TREATMENT OF ANTICHOLINESTERASE POISONING. IV: THE EFFECTIVENESS OF FIVE BINARY COMBINATIONS OF CHOLINOLYTICS WITH OXIMES IN THE TREATMENT OF ORGANOPHOSPHORUS POISONING

Authors
  1. Coleman, I.W.
  2. Little, P.E.
  3. Patton, G.E.
  4. Bannard, R.A.B.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
The following combinations had highest and almost equal effectiveness: G3063, a Caramiphen hydrochloride (Parpanit (TRADEMARK)) analogue, with trifluopromazine; and Win 5779-6, a benzilate type ester, with triflupromazine. The combinations of Win 5779-6 with Parpanit (TRADEMARK), atropine methylbromide with Parpanit (TRADEMARK), and G3063 with G5130, another Parpanit (TRADEMARK) analogue, were second in activity and almost equal in potency. Atropine sulfate was the least effective. The most effective oximes were TMB4, and a lower dose mixture of P2S plus TMB4, which were found almost equal in potency but superior in effectiveness to P2S alone.
Report Number
DCBRL-456A — Reprint; Previously accessioned as DSIS 66-14084
Date of publication
15 Sep 1965
Number of Pages
21
Reprinted from
Canadian J of Physiology and Pharmacology, vol 44, 1966, p 745-764
DSTKIM No
92-03837
CANDIS No
127170
Format(s):
Hardcopy;Originator's fiche received by DSIS

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