THE ROLE OF THIOL GROUPS IN THE DEVELOPMENT OF RADIATION DAMAGE IN THYMOCYTES AND EHRLICH ASCITES CARCINOMA CELLS

Authors
  1. Scaife, J.F.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
The effect of 800-1000 rads of X-irradiation on the thiol content of thymocytes and Ehrlich ascites carcinoma cells has been compared. The ratio of NP.SH/P.SH is higher in thymocytes than in ascites cells, but, allowing for the difference in cell size, the overall total thiol concentration was the same. It is concluded that, if thiol groups are involved in cell sensitivity to radiation, only a small fraction of the total SH groups are involved at critical sites. The most likely explanation for the role of the thiols in cell sensitivity is that a small number of the many SH groups in the cell are involved in sensitive intermolecular or intramolecular bondings betwen macromolecules constituting active subcellular structures, whose function and integrity is critically affected by relatively low doses of radiation.
Keywords
Ehrlich tumor
Report Number
DCBRL-440 — Reprint; Previously accessioned as DSIS 65/01715
Date of publication
15 May 1964
Number of Pages
12
Reprinted from
Canadian J of Biochemistry, vol 42, 1964, p 1717-1727
DSTKIM No
92-03856
CANDIS No
127185
Format(s):
Hardcopy;Originator's fiche received by DSIS

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