THE PROTECTION OF SOME BEHAVIORS AGAINST THE EFFECTS OF NERVE AGENT IN THE RAT

Authors
  1. Morris, P.
  2. Tsang, R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Grant (G A) Scientific Consultants Ltd, Nepean ONT (CAN)
Abstract
The investigation determined the residual behavioral capacity of rats following administration of nerve agent and the putative treatment for nerve agent exposure, using a test battery which measured several major categories of behavioral function. After training to asymptoteperformance in a paradigm for cognitive function (either conditioned approach (operant) behavior or conditioned avoidance behavior), groupsof rats were injected with soman (either 1 LD50 (85 ug/kg) or 2 LD50 (170 ug/kg), s.c.) and the treatment compounds atropine (17 mg/kg, i.p.) and HI-6 (125 mg/kg, i.p.); and additional group received injections of only atropine and HI-6. Following recovery, rats were tested again in the paradigm for cognitive function, as well as in other tests ofmotor function (spontaneous motor activity), motivational function (drinking behavior), or emotive function (conditioned taste aversion).
Report Number
DRES-CR-41-92 — Contract Report (Final)
Date of publication
01 Jan 1992
Number of Pages
90
DSTKIM No
93-00099
CANDIS No
127351
Format(s):
Hardcopy;Originator's fiche received by DSIS

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