PROTECTIVE EFFECT OF LIPOSOME-ASSOCIATED ALPHA-TOCOPHEROL AGAINST PARAQUAT-INDUCED ACUTE LUNG TOXICITY

Authors
  1. Suntres, Z.E.
  2. Hepworth, S.R.
  3. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The present study was undertaken to investigate whether alpha-tocopherol, entrapped in liposomes and delivered directly to the lung, could protect against paraquat-induced lung damage in the rat. Plain liposomes (composed of dipalmitoylphosphatidylcholine, DPPC) or DPPC/alpha-tocopherol liposomes were administered intratracheally to animals 24h prior to an intraperitoneal injection of paraquat (20 mg/kg); rats were killed 24 or 48 h after paraquat treatment. Results of this studyshowed that lungs of animals treated with paraquat were extensively damaged as evidenced by an increase in lung weight and a significant reduction in lung angiotensin converting enzyme (ACE) activity and cytochrome P-450 concentration. Furthermore, paraquat treatment resulted ina significant decrease in reduced glutathione (GSH) concentrations and a marked elevation in microsomal lipid peroxidation levels as measured by the formation of diene conjugates. TRUNCATED
Report Number
DCIEM-92-P-21 — Research Paper; Reprint
Date of publication
01 Jan 1992
Number of Pages
8
Reprinted from
Biochemical Pharmacology, vol 44, no 9, 1992, p 1811-1
DSTKIM No
93-00240
CANDIS No
127467
Format(s):
Hardcopy;Originator's fiche received by DSIS

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