EFFECTS OF EPHEDRINE/XANTHINES ON THERMOGENESIS AND COLD TOLERANCE

Authors
  1. Vallerand, A.L.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The paper reviews the use of ephedrine (E) and xanthines (X) to improve thermogenesis and cold tolerance. Recent experiments in cold-exposed subjects have shown that the beneficial effects of ingesting an E/caffeine (C) capsule on metabolic rate (M), heat debt, deep body core temperature (T sub re) (P<0.05) is entirely comparable to that observed with an E/C/theophylline (T) capsule. Although T has been reported to reduce the drop in T sub re in several studies, these improvements are difficult to explain in the absence of changes in M. A theobromine-based commercial sports bar (Cold Buster (trademark)) has been similarly shown to reduce the drop in T sub re. However, such a claim could not be confirmed in our lab. Despite an increase in M in some studies, C had no effect on T sub re in the cold. It is concluded that E/X represent, at the moment, the best pharmacological agents to enhance cold thermogenesis and to delay the onset of hypothermia in humans.
Keywords
Ephedrine
Report Number
DCIEM-92-43 — Reprint; Conference Paper
Date of publication
01 Sep 1992
Number of Pages
4
Reprinted from
International J of Obesity, vol 17, suppl 1, 1993, p S53-S56
DSTKIM No
93-02669
CANDIS No
129712
Format(s):
Hardcopy;Originator's fiche received by DSIS

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