LIPOSOMES AS A TOPICAL OCULAR DRUG DELIVERY SYSTEM

Authors
  1. Barber, R.F.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Exposure to potential air-borne toxic agents is an occupational risk for several professional groups in both civilian and military sectors. The eyes are highly vulnerable to any toxic exposure because of their readily accessible location in the body. In order to provide adequate in situ protection to the eye, it is necessary to develop a carrier system which can enhance the delivery of a prophylactic drug to ocular tissues. Conventional eye drops deliver drugs in a pulsatile fashion with a very brief period of over-dosing immediately after instillation, followed by a rapid decline to insignifcant levels. Liposomal ophthalmic formulations, on the other hand, show promise in improving ocular drug delivery. Liposomes are biocompatible and biodegradable lipid microcapsules which may serve as a depot system to achieve a slow, sustained drug release effect. The key advantage of liposomal formulations resides in the versatility of custom-designed liposomes to meet specific needs by their variations in size, surface charge and lipid composition. The pharmacokinetics of ophthalmic drugs entrapped in liposomes can be altered to promote local prophylactic and therapeutic efficacies. The extent and pattern of alteration are primarily determined by the method of ocular application and the physicochemical nature of the liposome-drug complex. TRUNCATED
Report Number
DCIEM-92-P-22 — Research Review Paper: Reprint
Date of publication
01 Jan 1993
Number of Pages
20 approx
Reprinted from
Pharmaceutical Particulate Carriers: Therapeutic Applications, New York, Marcel Dekker, (US), 1993
DSTKIM No
93-04653
CANDIS No
134242
Format(s):
Hardcopy;Originator's fiche received by DSIS

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