COMPLEMENT ACTIVATION INVOLVEMENT IN DECOMPRESSION SICKNESS OF RABBITS

Authors
  1. Ward, C.A.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Mechanical Engineering;Hospital for Sick Children, Toronto ONT (CAN) Research Inst
Abstract
A hypothesis has been proposed that claims much of the phenomena of decompression sickness (DCS) are mediated by the complement system of blood plasma. This "complement hypothesis" can be used to explain the variation in susceptibility of individuals to DCS, including the phenomena of acclimatization and de-acclimatization. In this study, certain predictions of the complement hypothesis were examined by exposing rabbits to a particular pressure profile; some were observed to have symptoms of DCS and some showed none. Those that were observed to have symptoms were also found to have native complement systems that were activated by air bubbles, and those that did not show symptoms of DCS when exposed to the same pressure profile had native complement systems that were not activated by air bubbles. Rabbits that had shown symptoms of DCS the first 2 times that they were exposed to the pressure profile could be acclimatized to the pressure profile by pharmacologically decomplementing them in vivo. After being decomplemented, they showed no symptoms of DCS when they were exposed to the same pressure profile for a third time. TRUNCATED.
Report Number
DCIEM-90-P-29B — Research Paper; Reprint
Date of publication
10 Oct 1989
Number of Pages
16
Reprinted from
Undersea Biomedical Research, vol 17, no 1, 1990, p 51-65
DSTKIM No
93-04969
CANDIS No
134678
Format(s):
Hardcopy;Originator's fiche received by DSIS

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