STUDY OF VACCINATION AND TREATMENT AGAINST BRUCELLA SPP

Authors
  1. Frank, J.F.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);United Nations Univ, Tokyo (Japan)
Abstract
The purpose of this project was to isolate and characterize Brucella genes coding for proteins that are importnt for the understanding of pathogenic mechanisms and developing protective therapies. More than 300 DNA fragments coding for Brucella abortus proteins have been clones. To limit the selection of a clone for further study, 2 key ones were chosen because these coded for proteins, 18,000 and 28,000 m.w., that reacted with hyperimmune sera or sera from infected animals but not vaccinated animals, respectively. The significance of the 28 kd protein as a potent toxin and possibly a novel vaccine is discussed.
Report Number
DRES-CR-93-21 — Contract Report
Date of publication
08 Jul 1993
Number of Pages
93
DSTKIM No
93-04486
CANDIS No
135324
Format(s):
Hardcopy;Originator's fiche received by DSIS

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