PURIFICATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES (MCA) OF FRANCISELLA TULARENSIS

Authors
  1. Schryvers, A.B.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The ultimate goal of this rsearch is to obtain a stable supply of good quality antibody that is specific for identification of Francisella tularensis and/or potentially useful as immunotherapeutic reagents for infection. The major task was to screen a collection of hybridoma cell lines provided by DRES for; (i) cell viability, (ii) stability/monoclonality, (iii) antibody production, (iv) specificity of antibody, and (v) ability to induce ascites. Due to the short duration and limited support of this contract, the requirements for fulfilling the actual contract merely required completion of the first objectives. However, work was initiated on all five objectives in order to facilitate ultimate achievement of the overall goal. For completion of this contract we focussed on attempting to identify potentially useful hybridoma lines and returning the clones and any ascites produced at the termination of the contract.
Keywords
Francisella tularensis
Report Number
DRES-CR-93-26 — Contract Report (Final)
Date of publication
01 Apr 1992
Number of Pages
5
DSTKIM No
93-04633
CANDIS No
135341
Format(s):
Hardcopy;Originator's fiche received by DSIS

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