DISTRIBUTION OF FREE AND LIPOSOME-ENCAPSULATED CEFOXITIN IN EXPERIMENTAL INTRA-ABDOMINAL SEPSIS IN RATS

Authors
  1. Kresta, A.
  2. Shek, P.N.
  3. Odumeru, J.
  4. Bohnen, J.M.A.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The distributions of radiolabelled free cefoxitin (FC) and liposome-encapsulated cefoxitin (LC) were compared in an animal model of intra-adbominal sepsis. Introperitoneally administered LC was initially retained inthe peritoneal cavity with subsequent preferential drug targeting to the liver (14% injected LC) and spleen (6% injected LC) by 3 h post-injection. Differing patterns of liposomal drug and lipid retention indicated that drug release from the liposome complex occurred within the peritoneum, liver and spleen. Intraperitoneally FC was rapidly taken up into the systemic circulation, with peak recovery in the blood (9% injected FC) and liver (5% injected FC) at 1 h post-injection. FC was also rapidly eliminated; 7% of the injected drug was recovered in the kidney 1 h post-injection. A negligible amount of FC was recovered in the spleen and very little FC or LC was found in the lungs of treated animals. Unlike FC, LC was found to provide a sustained bactericidal drug level (>40 mu g mL1(-)) in the peritoneal fluid for up to 5 h post-injection. LC also achieved significantly higher drug levels, compared with FC, within the liver at 3 and 5 h post-injection. TRUNCATED
Date of publication
18 Dec 1992
Number of Pages
5
Reprinted from
J Pharm Pharmacol, no 45, 1993, p 779-783
DSTKIM No
93-04916
CANDIS No
135521
Format(s):
Hardcopy;Originator's fiche received by DSIS

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