THE ROLE OF COMPLEMENT ACTIVATION IN DECOMPRESSION SICKNESS

Authors
  1. Ward, C.A.
  2. McCullough, D.
  3. Yee, D.
  4. Stanga, D.
  5. Fraser, W.D.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Mechanical Engineering;Hospital for Sick Children, Toronto ONT (CAN) Research Inst
Abstract
Previous studies have indicated that the sensitivity of an individual to complement activation determines his susceptibility to decompression sickness (DCS). Other studies have suggested that bubble-induced platelet aggregation also plays a key role in DCS. An investigation of the role of complement activation in bubble-induced platelet aggregation is reported. It is shown that incubation of air bubbles with rabbit plasma has an effect on an agent in plasma and that it induces platelet aggregation when a sample of the incubated plasma is incubated with a substance, zymosan, that is known to strongly activate the complement system. The degree of platelet aggregation increases with the degree of complement activation in the incubated plasma samples and if the rabbits were pharmacologically decomplemented before their plasma was collected and incubated with either zymosan or with air bubbles, it was observed that the incubated plasma no longer induced platelet aggregation. It is suggested that is the anaphylatoxins C3a and C5a that are produced when air bubbles are incubated with plasma that are responsible for the air-bubble induced platelet aggregation. Fibrinogen does not appear to play an important role in air-bubble induced platelet aggregation.
Report Number
DCIEM-RP-88-39B — Research Paper
Date of publication
01 Jan 1989
Number of Pages
26
DSTKIM No
93-04897
CANDIS No
135530
Format(s):
Hardcopy;Originator's fiche received by DSIS

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